Examples include fusion RP11–444D3.1::SOX5, previously implicated in endometrial cancer (Yao et al. 2019) and meningioma (Viaene et al. 2019) and recently reported as found in normal tissues in glioblastoma (Hernandez et al. 2022), but found here in small numbers of malignant (7) and normal (3) cells in the melanoma tumor sample and similarly identified among small numbers of cells (2 to 11) among each of the three HGSOC patient samples sets of tumor and matched normal samples. The gene discussed is SOX5; the disease is melanoma.