As one example, mice with a keratinocyte-specific mutation of the lipid transport protein, acyl-CoA-binding protein (ACBP), show impaired thermal barrier function (increased TEWL), increased energy expenditure and food intake, altered lipid metabolism in liver, increased lipolytic flux in white adipose tissue (WAT), iWAT beiging, and resistance to diet-induced obesity. Here, DBI is linked to obesity due to melanocortin 4 receptor deficiency.