ChIP enrichment analysis revealed the possible involvement of FOXM1, E2F1 and E2F4, SOX2, KLF4, and MYBL2 transcription factors in the pathogenesis of PTCL as they may play a role in the deregulation of the ‘Core PTCL Expression Signature’ (Fig. S9). The gene discussed is E2F1; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.