We show that both TRIP13 knockdown and its pharmacological inhibition by a small-molecule inhibitor DCZ0415 impaired cellular growth of T-cell lymphoma cell line T8ML-126, as well as T-cell leukemia cell lines by inducing G2-M arrest and apoptosis suggesting the role of this gene in maintenance of T-cell malignancies. Here, TRIP13 is linked to T-cell leukemia.