The TOP five genes overexpressed in all PTCL samples encode the following: phospholipase PLA2G2D, organic anion transporting polypeptide SLCO2B1, metalloprotease ADAMDEC1, complement protein C1QB, and receptor activity modifying protein RAMP3, with the average increase in expression over 500-fold. The gene discussed is PLA2G2D; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.