Ingenuity Pathways Analysis (IPA) of differentially expressed genes [FC ≥ 1.5, p< 0.05 by DESeq2) in human T-cell lymphomas (n = 10) relative to control T-cells (n = 4)] revealed that all PTCLs had Inhibited Pathways related to Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes, T Cell Receptor Signaling, and HIPPO signaling (Fig. 3B). Here, IL2 is linked to T-cell non-Hodgkin lymphoma.