TNF and Crohn ileitis: We go on to reveal that selective blockade of LTα333, a ligand that does not bind LTbR but instead binds to TNFRs I and II with high affinity and HVEM with lower affinity32, has an independent role in controlling body weight of mice with ileitis in a manner that suggests that it may compete with TNFa to attenuate some of the disease-promoting pathology that result from chronic overproduction of TNFa.