ARA = angiotensin receptor antagonists; ACEI = ACE inhibitors; BB = β-adrenoceptor antagonists; combined = all studies combined; CCA = calcium channel antagonists; control = antihypertensive drug utilized as comparator drug in that research; lower = lower limit of 95% CI of OR; OR = odds ratio; p-value = p-value of difference between nebivolol and control; upper = upper limit of 95% CI of OR Nebivolol and other b blockers have been the subject of several clinical trials as the management of hypertension has gained increasing attention. The gene discussed is ACE; the disease is hypertensive disorder.