Apart from TUBA4A, other genes involved in cytoskeleton integrity have also been linked with ALS, namely DCTN1, KIF5A, PRPH, NF-H, PFN1 and SPAST (Chakraborti et al., 2016; Guo et al., 2020). The gene discussed is TUBA4A; the disease is amyotrophic lateral sclerosis.