Furthermore, in the adipose tissue under HF-fed rat abdominal skin, decreased expressions of Nrf2 and HO-1 were detected by Western blot (Figure 2d and e, P < 0.001), while these HF-caused decreases of Nrf2 and HO-1 expressions were resisted by either Met or L-car (Figure 2f–h, P < 0.05). This evidence concerns the gene NFE2L2 and hydrops fetalis.