However, Met or L-car monotreatment can restore the expressions of these genes in the adipose tissues of HF-fed rats under their abdominal skin (Figure 2a–c, P < 0.001), and also the combined treatment of Met and L-car was more effective in increasing expressions of UCP1, PRDM16, and PGC1α in the adipose tissue under their abdominal skin than Met or L-car monotreatment (Figure 2a–c, P < 0.001). This evidence concerns the gene PPARGC1A and hydrops fetalis.