These subtypes are then further classified into additional subtypes, including ARCL-1A, ARCL-1B, ARCL-1C (also called Urban-Rifkin-Davis syndrome), ARCL-2A, ARCL-2B, ARCL-3A (also called De Barsy syndrome A), and ARCL-3B (also called De Barsy syndrome B) [41]. Here, PYCR1 is linked to cutis laxa with severe pulmonary, gastrointestinal and urinary anomalies.