expression, bbb, cns, diseases, cells, role, gene, genes, cell, barrier, mirnas, evs, hmgb1, therapeutic, calpain, complement, activation, neuronal, system, bloodbrain, inflammatory, exosomes, potential, extracellular, mice, disease, proteins, neurological, protein, nervous, target, immune, rna, vesicles, pathway, disorders, central, signaling, noncoding, molecular, rnas, inflammation, may, glioma, endothelial, also, micrornas, mechanisms, neuroinflammation, development. The gene discussed is HMGB1; the disease is central nervous system cancer.