SCFAs via FFARs (free fatty acid receptors) binding can induce the release of anorexigenic peripheral hormones (PYY, GLP-1) that can modify insulin, leptin, and ghrelin concentration, though they can also influence hypothalamic release of pro-opiomelanocortin (POMC) and cocaine-and-amphetamine-regulated transcript (CART), orexigenic neuropeptide Y (PNY), and agouti-related peptide (AgRP) that can ultimately modify eating behavior and the related dimensions of cognition, impulsivity, mood and anxiety [12]. The gene discussed is POMC; the disease is Anxiety.