A. muciniphila significantly improved glucose intolerance in both lean and obese mice, reducing mRNA expression levels of glucose-6-phosphatase (G6Pase) and phosphoenolpyruvate carboxykinase (PEPCK), key enzymes in hepatic gluconeogenesis, thus ameliorating olanzapine associated insulin resistance. The gene discussed is G6PC1; the disease is Glucose intolerance.