Furthermore, we identified that in cancer patients with genetic alteration of PAICS showed a poor prognosis in OS (p = 5.08e−12), PFS (p = 5.16e−3), disease‐specific survival (DSS) (p = 3.003e−3), and disease‐free survival (DFS) (p = 0.0131), compared with patients without PAICS alterations (Figure S1C). This evidence concerns the gene PAICS and cancer.