To reveal the mechanism that the EGFR wild‐type NSCLC cells were more sensitive to the PAICS intervention, we performed the following experiments: first, we identified that the level of IMPDH2, a key enzyme in the de novo purine biosynthesis pathway, is significantly lower in EGFR mutant NSCLC cells than EGFR wild‐type NSCLC cells. Here, IMPDH2 is linked to non-small cell lung carcinoma.