As a result, PAICS, a putative bifunctional enzyme involved in histidine de novo purine biosynthesis with both 5‐aminoimidazole ribonucleotide carboxylase and 4‐(N‐succinylcarboxamide)−5‐aminoimidazole ribonucleotide synthetase (SAICARs) activities, was identified as a new therapeutic target for EGFR wild‐type NSCLC.17 Here, EGFR is linked to non-small cell lung carcinoma.