Next, we identified that the level of Inosine‐5′‐monophosphate dehydrogenase (IMPDH2), a key enzyme in the de novo purine biosynthesis pathway, is significantly lower in EGFR mutant NSCLC cells (PC9 and H1975) than EGFR wild‐type NSCLC cells (H1299 and A549) (p < 0.0001;, Figure S4A). This evidence concerns the gene EGFR and non-small cell lung carcinoma.