To further clarify whether the regulatory effect of TOX3 on the malignant biological behavior of HCC cells depends on IGFBP3, we knocked down IGFBP3 in TOX3‐overexpressing HCCLM3 cells and overexpressed IGFBP3 in TOX3‐knockout HCCLM3 cells. Here, IGFBP3 is linked to hepatocellular carcinoma.