Repeat expansions in the C9ORF72 gene and mutations in superoxide dismutase 1 (SOD1) are common genetic causes of ALS, while TAR DNA-binding protein (TDP-43) and fused in sarcoma/translated in liposarcoma (FUS/TLS) mutations represent a smaller fraction [165]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.