Thrombosis accounts for one out of every four deaths globally,and the prevalence of this condition is expected to rise with theaging population.17 Anticoagulants playa crucial role in preventing and treating thrombosis, emphasizingthe worldwide demand for agents that are both effective and safe.Studies indicate that the clotting process is always initiated withthe FVIIa/TF complex of the extrinsic pathway (Figure 2). Here, TF is linked to deep vein thrombosis.