The present study showed that the live formof B.coagulans BC198 ameliorated the severity of colitis(Figure 1B), preventedcolon shortening (Figure 1F), and reduced colitis-induced inflammation and damage tocolon tissue (Figure 2E,F) by reducing neutrophil and M1 macrophage infiltration of colontissue (Figure 3),possibly by enhancing the gut barrier function (Figure 4) and increasing the levels of Treg cellsand the anti-inflammatory cytokine, IL-10, in the colon (Figure 5). Here, IL10 is linked to colitis.