miR-146a-5p and miR-155-5p could be shifted from CRC cells to CAFs via exosomes and expressed in CAFs by regulating JAK2-STAT3/NF-κB signaling and targeting SOCS1 and ZBTB2 to accelerate the activation of CAFs, and the activated CAFs could enhance the intrusion capability of CRC cells. Here, STAT3 is linked to colorectal carcinoma.