demonstrated that CAFs-derived exosomes might accelerate cell proliferation and regulate apoptosis by RIG-I/IFN-β signaling and influence the chemosensitivity of ESCC to DDP, and that targeted inhibition of the RIG-I/IFN-β signaling axis in the exosomes of CAFs maybe an underlying therapeutic tactics for ESCC. Here, IFNB1 is linked to esophageal squamous cell carcinoma.