JAK2 and colorectal carcinoma: miR-146a-5p and miR-155-5p could be shifted from CRC cells to CAFs via exosomes and expressed in CAFs by regulating JAK2-STAT3/NF-κB signaling and targeting SOCS1 and ZBTB2 to accelerate the activation of CAFs, and the activated CAFs could enhance the intrusion capability of CRC cells.