Combined results showed that high TLR4 expression was significantly associated with larger tumor size (≥2 cm)(OR=2.194, 95%CI= 1.398-3.445, P= 0.001; Figure 2B),there was no heterogeneity in the results(P =0.152, I2 = 40.3%).We analyzed six studies using the fixed-effect model and found that high TLR 4 expression was associated with a more advanced clinical stage (OR = 3.578, 95%CI= 3.578-5.817, P<0.05; Figure 2C) with no heterogeneity (P =0.358, I2 = 9.1%). The gene discussed is TLR4; the disease is neoplasm.