Of all the included studies, ten, five, six, eight, four, four and five reported data on TLR4 in lymph node metastasis, tumor size, clinical stage, histologic grade, ER, PR and HER-2 respectively and three studies reported data on the association of TLR4 with survival outcomes. The gene discussed is TLR4; the disease is metastatic malignant neoplasm in the lymph nodes.