MMP9 and Hepatic fibrosis: In addition, daclatasvir has been shown previously to downregulate MMP9 in rat models of hepatic fibrosis (Zakaria and El-Sisi, 2020), along with other immunoregulatory factors, but did not have an effect on MMP9 mRNA or protein in the RDEB fibroblasts (Appendix Fig. S5C).