CR has been shown to shape the TME in several ways, including through the specific reduction in the number of TAMs, increase in the formation of CD8+ cytotoxic T cells and memory T cells, and negative modulation of immunosuppressive Treg cell activity and immunosuppressive cytokine levels.117 Additionally, CR promotes favorable changes in the immune signature, providing enhanced protection against tumor growth and metastasis, possibly in part by remodeling the TME. This evidence concerns the gene CD8A and neoplasm.