IFNG and neoplasm: As a result, the two primary types of MDSCs acquired different phenotypes: M-MDSCs differentiated into antitumor macrophages, and PMN-MDSCs adopted a proinflammatory phenotype, which led to the reactivation of T-cell antitumor functions.185 Furthermore, a high salt level has been found to induce the transformation of anti-inflammatory Tregs into proinflammatory Th1 cells, which led to the secretion of the inflammatory cytokine IFNγ.186 In another study, salt functioned as an adjuvant that enhanced the effectiveness of anti-PD-1 immunotherapy in tumor regression.