CD8A and colonic neoplasm: The downregulation of HO-1 production in cancer cells, in part, facilitated FMD-induced chemosensitization of cancer cells by boosting CD8+ TIL-dependent cytotoxicity, which was possibly facilitated by decreased Tregs.136 A separate study conducted with mouse models of colon cancer indicated that alternate day fasting for 2 weeks triggered autophagy in cancer cells, which in turn downregulated CD73 expression.