This is primarily due to the recruitment of macrophages and the overexpression of inducible NO synthase as a result of HFD.201 Additionally, in response to HFD intake, IL-6-mediated inflammation has been shown to accelerate prostate cancer tumor growth and increase the fraction of MDSCs and the M2/M1 macrophage ratio.202 The effects of diet-induced obesity extend to the microenvironment of colitis-associated CRC. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.