Feeding mice with the KD resulted in a noteworthy decrease in the expression of immune inhibitory receptors (PD-1 and CTLA-4) on CD8+ TILs, as well as a reduction in the expression of inhibitory ligands (CD86 and PD-L1) on cancer cells.152 These findings suggest that a KD has the potential to attenuate tumor-induced T-cell suppression by decreasing the population of cells susceptible to the inhibitory PD-1 pathway. The gene discussed is CD8A; the disease is neoplasm.