M1-like macrophages prevalently engage the FAS pathway, while M2-like macrophages predominantly utilize the mitochondrial FAO pathway for their bioenergetic demands.70,71 Receptor-interacting protein kinase 3 (RIPK3), which is crucial for necroptosis, is found to be diminished in hepatocellular carcinoma (HCC)-associated macrophages, leading to inhibited caspase1-mediated cleavage of PPAR, a process vital for enhancing fatty acid metabolism, including FAO. Here, FAS is linked to hepatocellular carcinoma.