CD8A and neoplasm: In multiple mouse models, reducing dietary methionine inhibited tumor growth and boosted antitumor immunity by increasing the quantity and cytotoxicity of tumor-infiltrating CD8+ T cells.162 Moreover, restricted intake of dietary protein or methionine/cystine has been shown to modify the infiltration and tumoricidal capacity of TAMs, leading to a significant increase in tumor-infiltrating CD8+ T cells and a decrease in the number of infiltrating MDSCs.