In a group of melanoma biopsies that had not been treated with PD-1 inhibitors, it was observed that higher levels of miR-100-5p (p-value = 0.036) and miR-125b-5p (p-value = 0.025) expression were linked to better results when treated with anti-PD-1 immunotherapy [91]. This evidence concerns the gene PDCD1 and melanoma.