With respect to the two identified markers in the model, SFRP2 was reported as a top biomarker of a predominant CAF population and inactivation of SFRP2 in CAFs impaired their ability to induce the migration and invasion of colon cancer cells, as well as their tumorigenicity in vivo by creating an immunosuppressed environment [48]. Here, SFRP2 is linked to colonic neoplasm.