To investigate the association between KCNE4 expression and CAF infiltration in various cancer microenvironments, we utilized a range of algorithms, including EPIC, MCP-counter, XCell, and TIDE, available on the TIMER2.0 database, and obtained evidence demonstrating a positive correlation with a particular emphasis on CRC (Fig. 4a). Here, KCNE4 is linked to colorectal carcinoma.