SMC1A and Global developmental delay: Consistent with the body of literature that highlights more severe clinical symptoms among those with NIPBL than those with other CdLS-causative variants [12, 14], we hypothesized that those with a pathogenic variant in NIPBL will present with more severe developmental delays, enroll in more intervention services (speech, occupational, and/or physical therapies) and demonstrate more challenging behaviors than those with an SMC1A variant.