TREM2 and Alzheimer disease: In this review, we further compared newly developed AD mouse models (e.g. TREM2 KO/KI and Tg mouse models, the MODEL-AD consortium LOAD mouse models, SAMP8 and seeding models) with previously well-established mouse models, including phenotypic characterization along with discussions of any sex-specific features (as summarized in Tables 1 and 2).