MAPT and Alzheimer disease: For example, in 5xFAD mice, inoculation of α-synuclein preformed fibrils in 5xFAD mice led to accelerated seeding and spread of α-synuclein and tau, as well as exacerbated AD pathology including increased amyloid plaque burden, tau hyper-phosphorylation and neurite dystrophy when compared to wt mice inoculated with α-synuclein seeds [167].