MAPT and Alzheimer disease: It has been noted that 5xFAD mouse models demonstrated a significant overlapping of human AD molecular signatures other than amyloid and tau pathology such as neuroinflammation, endo-lysosomal function and synapse formation, supporting the notion that this model showed most significant overlapping with human AD molecular signature and is probably a preferable mouse model to study certain AD processes such as neuro-inflammation and endo-lysosomal dysfunction.