Considering the association of CaMKIIa with NFT in AD [48, 49] and the facilitating effects of NaV1 on microtubule-actin cross talk [50], it is plausible that CaMKIIa and NaV1 may play a role in AD-like tau pathology within the vCA1, either independently or in combination. The gene discussed is MAPT; the disease is Alzheimer disease.