To outline tau pathology in the hippocampus during AD-like progression, we used an AT8 antibody to detect phosphorylated paired helical filament tau [35] in male 3xTg-AD mice at different ages, specifically focusing on the ventral-dorsal axis (which corresponds to the anterior–posterior axis in humans [36]) of the hippocampus. This evidence concerns the gene MAPT and Alzheimer disease.