In addition, the presence of Pd@Au-PEG-TCO provides an abundance of active binding sites for the dual-targeting DOTA-PSMA-Tz during the third step, whereby PSMA and Pd@Au-PEG-TCO were effectively targeted to enhance its tumor uptake and improve the target-to-non-target (T/NT) ratios. Here, FOLH1 is linked to neoplasm.