The results showed that (1) smokers account for a high proportion of elderly Chinese males with schizophrenia; (2) smoking has no effect on overall cognitive function in older men with chronic schizophrenia; (3) smoking was harmful to the health of elderly patients with schizophrenia but could effectively prevent negative symptoms; and (4) there was a negative correlation between daily cigarette consumption and plasma albumin in older men with chronic schizophrenia. Here, ALB is linked to schizophrenia.