While we did not find altered DEK expression in neurons in a recent single cell transcriptomics study of the EC in human AD,54 its function can be regulated by post-translational modifications64 and by degradation.65 Further studies will be necessary to assess DEK activity levels during prodromal AD, as well as to elucidate the functional impact of genetic variation in DEK, like the rs145578678 polymorphism. This evidence concerns the gene DEK and Alzheimer disease.