MAPT and Alzheimer disease: A feature of this framework, compared to previous studies,61-63 is that it models gene networks for a unique neuron type as opposed to a whole brain region, and it is the first one to integrate quantitative genetics11 and in vivo genomics data for AD vulnerable neurons.61-63 It is, thus likely to identify genes that are indeed regulating tau during the natural course of human AD within ECII neurons, especially during early disease stages.