MAPT and Alzheimer disease: To investigate AD processes in the specific context of ECII neurons, we used the NetWAS 2.0 (Network-Wide Association Study 2.0) algorithm, which leveraged our ECII functional map along with genome wide association study data for NFT formation.14,15 NetWAS 2.0 reprioritized genes based on their association with tau pathology within vulnerable neurons and identified four gene modules—groups of genes with predicted common involvement in biological pathways—potentially contributing to NFT formation in AD.