We next tested whether DEK indeed regulates genes from the AD vulnerability module identified by NetWAS 2.0.14 Genes in the vulnerability module were indeed more differentially expressed after Dek silencing in vivo than expected by chance (P-value = 1.76 × 10−07, Fisher’s exact test), thereby validating DEK as a regulator of this module, with the potential to affect pathological mechanisms in ECII. Here, DEK is linked to Alzheimer disease.