DEK and Parkinson disease: Interestingly, Dnajc6, which codes for auxilin, a protein necessary for lysosomal degradation of autophagosome content with mutations associated with Parkinson’s disease,51 was among the most significantly downregulated genes in Dek-silenced EC neurons both in vitro and in vivo (log2FC = −2.1, Padj = 4.9 × 10−145; log2FC = −0.6, Padj = 0.008, respectively).