TICAM1 and COVID-19: Importantly, JL Casanova and colleagues identified single-gene mutations associated with type I interferon signaling pathways (TLR3, IRF7, IRF3, TICAM1/TRIF, UNC93B1, TBK1, IFNAR1, and IFNAR2) in COVID-19 patients that may result in life-threatening outcomes in life-threatening cases of COVID-19 pneumonia [9].