Overexpression of HDAC5, but not EYFP, reduced plaque size for CPXV-BR (Figures 4I and 4J) and reduced the yield of infectious virus for CPXV-BR, CMLV, CPXV-E, and RPXV 2 days after infection (Figures 4K–4M and S3E). The gene discussed is HDAC5; the disease is infection.