,16,17,18,19 HDAC3, HDAC4, HDAC5, and HDAC11 restrict infection of some viruses via regulation of IRF3, nuclear factor κB (NF-κB), or type I interferon (IFN) Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathways.11 Here, IRF3 is linked to infection.