(4) In the 3 species, the classical CB1/2 receptors—alone and in combination with other receptors and channels (Supplementary Fig. S3)—are implicated in the regulation of a complex network of pain related disorders, functions, processes, pathways, and phenotypes coupled with a set of sensory perception, cancer-specific, pro-inflammatory, and immuno-modulatory activities. This evidence concerns the gene CNR1 and cancer.