A review of studies that were considered to be too heterogeneous to be included in the meta-analysis or not reported in a format unsuitable for pooling (Table 3) complement this conclusion by showing that administration of the endocannabinoid 2-AG or increasing its level by treatment with the MAGL inhibitor JZL-184 significantly reduced cancer-induced bone pain in mice, whereas AEA had no effects84. The gene discussed is MGLL; the disease is cancer.