CNR1 and sarcoma: Pooled analysis of studies in models of mechanical allodynia showed that intrathecal injection of the endocannabinoids 2-AG (MD − 32.09, 95%CI − 47.38, − 16.80) and AEA (MD − 19.26, 95%CI − 32.64, − 5.88) (CB1/2-non-selective) is associated with significant reduction in paw withdrawal frequency in adult male C3H/HeN mice inoculated with osteolytic sarcoma cells.