When we excluded the samples from the 14 TNFi-treated individuals from the analysis, the difference in TNF levels between JIA and controls changed from 1.04 (95% CI, 0.51 to 1.57) before exclusion (JIA, n = 42) to 0.18 (95% CI, -0.12 to 0.47) after exclusion (JIA, n = 28) (Fig. 2, A and C). This evidence concerns the gene TNF and juvenile idiopathic arthritis.