STAT4 and ovarian carcinoma: Up-regulated genes in LV versus RV in all three HF phenotypes include the previously mentioned STAT4, which has been reported as overexpressed in hypoxia-exposed human ovarian cancer tissue47, and ANKRD2 (Ankyrin repeat domain-containing protein 2), which functions as a negative regulator of myocyte differentiation and may interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress24.