NEAT1 and Alzheimer disease: Mechanistically, through acylation modification histology, ChIP-seq, and other approaches, NEAT1 has been confirmed to change the acylase activity of P300 by binding to P300 and changing H3K27ac and H3K27cr, which are situated close to the TSSs of a number of gene promoters, as well as by downregulating endocytosis-related genes to inhibit Aβ uptake in AD [61].