Consistent with the major profibrogenic cytokine TGF-β1, it has been found that the anti-inflammatory cytokine IL-10 is produced by alveolar macrophages, and another study further demonstrated that IL-10 suppresses lung fibrosis in a TGF-β1-dependent manner, wherein the overexpression of IL-10 simultaneously regulates the M2 polarization via the CCL2/CCR2 axis [82]. The gene discussed is CCL2; the disease is pulmonary fibrosis.