GZMB and neoplasm: Moreover, a minor to medium increase of GZMB expression and upregulation of activation of CD69, IFN-γ, CD25 and CD107 were detected in tumor-infiltrating CD8+ T cells from the B16F10 tumor graft after silencing Mi-2β, which was strongly augmented by anti-PD-1 treatment (Fig. 1f and Supplementary Fig. 1k).