Upregulations of Cxcl9, Cxcl10, Cxcl11, Ccl5, Tap1, CD74, Irf1, Icam1, CD40, Fas and PD-L1 were detected after Mi-2β silencing and the anti-PD-1 treatment in BRafV600E/Ptennull melanomas (Supplementary Fig. 4b). This evidence concerns the gene CHD4 and melanoma.