Furthermore, it has been observed that Th2 dominance is related with senile osteoporosis [66, 68], implying that Th2-type cytokines such as IL-10, IL-6, IL-5, and IL-4 levels rose while Th1-type cytokines such as IL-2,IFN-γ and TNF-α reduced in patients suffering from senile osteoporosis. Here, IL4 is linked to osteoporosis.