SHH and colorectal carcinoma: Previously, our data showed that gene microarray assay demonstrated that SLC26A9 gene modification resulted in many singling pathways alterations, including Wnt/β-catenin signaling, P53 singling pathway, SHH signaling pathway, MAPK signaling pathway and so on [12], Furthermore, the Wnt/β-catenin pathway is activated and β-catenin degradation is reduced, resulting in nuclear accumulation of β-catenin as well as transcription of downstream target genes in the development of CRC as reported [32].