Moreover, IHC analysis showed that SLC26A9 was localized in the cytoplasm and cell membrane of adjacent tissues with low expression levels (n = 168), but increased in polyps (n = 76) and adenomas (n = 107) and was especially significantly upregulated in colorectal adenocarcinoma (n = 190), with translocation to the nucleus (Fig. 1B). Here, SLC26A9 is linked to colorectal adenocarcinoma.