By comparing the results of the present study with those of our previous WES study combined with structural neuroimaging analysis in patients with MDD [32], we discovered several genes that were not identified in previous studies, such as XIRP2, MUC5B, FRMPD3, and MUC6. Furthermore, a previous study found a significant association between one SNP (rs11592462) of CDH23 and thinning of the right anterior cingulate cortex, whereas the present study did not find any association between CDH23 and DTI parameters. The gene discussed is MUC5B; the disease is major depressive disorder.