The overexpression of CUL7 has been reported in hepatocellular carcinoma41 and esophageal carcinoma.42 CUL7 protein level was associated with metastatic potential in breast cancer,43 ovarian cancer.44 FBXW11, one of the substrate receptors of CUL7, was also reported to promote the proliferation of lymphocytic leukemia cells and the metastasis of colorectal cancer.45,46 In this study, for the first time, we document the correlation between CUL7FBXW11 complexes and EGFR-TKI resistant phenotype (Fig. 4j, k). Here, EGFR is linked to breast carcinoma.