We found that SUMF1 expression was significantly correlated with glioma immune score, stromal score, ESTIMATE score, immune cells (aDC, B cells, CD8 T cells, cytotoxic cells, T cells, Tgd, Th17 cells, Th2 cells, and others), and immune cell markers (CD19, CD86, CD8B, CCL2, PDCD1, CD8A, CTLA4, CD79A, and others). This evidence concerns the gene CTLA4 and central nervous system cancer.