PBK and cancer: Mechanistically, in terms of biological significance, the EGFR-TKIs and mAbs exhibit obvious growth inhibition effect rather than inducing DNA fragmentation thus affecting cell survival in many types of EGFR-positive cancer cells, while our FHND004 affects both MM cell growth (increase in cell numbers or size) and survival (ability to keep alive under stresses) by targeting PBK rather than EGFR kinase in MM.