PBRM1 and cancer: Several residues defining the putative PBRM1-BD4 nucleic acid binding pocket (60) are near (e.g., R522, Y555, H599) or include (E583) the residues we consider in the cancer-associated PBRM1-BD4 missense variants analyzed in this study (i.e., M523R, P556S, E583K, and N601K).