PBRM1 and cancer: Overall, cancer-associated PBRM1-BD4 missense variants are destabilized (average of variants Tm = 44.3 ± 8.2 °C; ΔTm = −10.4 °C) relative to WT (Tm = 54.7 ± 0.5 °C) (Fig. 2A, Table S2).