PBRM1 and cancer: Since PBRM1 is a key chromatin-targeting subunit of the PBAF chromatin remodeling complex (14, 15, 16), the apparent increased nucleic acid binding of select cancer-associated PBRM1-BD4 missense variants may contribute to cancer pathophysiology through aberrant genomic targeting of the PBAF complex and altered transcriptional regulation (60, 66).