PBRM1 and nonpapillary renal cell carcinoma: Moreover, our results confirm and expand upon the disruptive effects of cancer-associated variants at conserved residues, such as Y580 and N601, on PBRM1-BD4 histone Kac binding capacity (Fig. 3A) and whole-protein suppressive effects on ccRCC cell growth (Fig. 6B) that have been noted in previous studies (23).