Although PBRM1 is often classified as a tumor suppressor (24, 25, 26), clinical observations correlating PBRM1 protein expression or mutational status with ICB and antiangiogenic response suggest that PBRM1 plays diverse roles in cancer (32, 33, 41, 42, 43, 44, 45, 67). The gene discussed is PBRM1; the disease is neoplasm.