6q deletions lead to the loss of crucial tumor-suppressor genes and immune regulators in the pathogenesis of mature lymphoid malignancies including PRDM1, SGK1, and TNFAIP3. 18Deletions of 9p21.3 were thought to be characteristic of leg-type DLBCL and conferring dismal prognosis.16 The gene discussed is PRDM1; the disease is diffuse large B-cell lymphoma.