In a recent report by Enocsson et al. investigating surrogate biomarkers to type I IFN in SLE, the authors indicated that both CXCL10 and CCL19 correlate stronger with anti-histone antibodies than did antibodies against dsDNA, SmRNP and SSA (Fig. 3 in [11]). This evidence concerns the gene TRIM21 and systemic lupus erythematosus.