EWSR1 is involved in the proliferation, metastasis, and metabolic reprogramming of multiple tumor types.[25, 45] It can bind to transcription factors to form fusion proteins and affect RNA stability and the alternative splicing process, thereby regulating the expression of downstream genes.[46, 47, 48] However, prior to our work, the mechanistic connection between LINC01116 and EWSR1 and the biological function of EWSR1 in the TME and immunotherapy were undetermined. Here, EWSR1 is linked to neoplasm.