In summary, TIMI flow grades of 0–1, levels of cTnI, persistent hypotension, reperfusion arrhythmias, the RCA as the IRA, the diameter of the IRA, renal dysfunction, levels of CK-MB, and bradycardia are identified as risk factors for the occurrence of ES following PCI in patients with AMI. This evidence concerns the gene TNNI3 and Bradycardia.