CD274 and neoplasm: Thereby, a PD‐1/PD‐L1 blocker BMS‐1 coupled with BAY‐876 was co‐loaded by thermogel (Gel@B‐B) to regulate the metabolism/immunity of GBM (Figure 1): 1) inhibit LA‐excretion from tumor cells, and 2) overcome immune resistance of tumor cells and TAMs.