Notably, we found that the inhibition of adipose HIF2α and its target gene levels in obesity could be alleviated by UMP supplementation (Figure 7F and Figure S7D, Supporting Information), but the activation of HIF1α and its target gene in obese mice were unaffected in this context (Figure S7B,C, Supporting Information), indicating that HIF2α was relevant to the capacity for UMP supplementation to alleviate obesity. This evidence concerns the gene HIF1A and obesity due to melanocortin 4 receptor deficiency.