ACER2 and Insulin resistance: The data showed that UMP‐induced reduction of body weight, liver weight, fat weight, serum, and hepatic cholesterol and triglyceride levels, together with insulin resistance, liver steatosis relief, and lipid accumulation in adipose tissue were lost in Hif2α△adipo mice (Figure 8A–N), and the upregulation of ACER2 by UMP was also prohibited (Figure 8O,P).