As an enzyme involved in monounsaturated fatty acid biosynthesis, SCD plays a pivotal role in regulating lipid peroxidation and ferroptosis.[24, 25] Inhibition or knockout of SCD increases lipid peroxidation and sensitizes cancer cells to ferroptosis, while overexpression of SCD protects against ferroptosis.[26] Existing literature reports that inhibiting SCD decreases cancer cell proliferation and enhances ferroptosis in GC cells.[27] This suggests that SCD could be a promising therapeutic target for GC treatment. The gene discussed is SCD; the disease is cancer.