CDKN2A and mesothelioma: Moreover, in murine models it has been shown that hypermethylation of p16INK4A or p19ARF (orthologous of the human p14ARF) precedes mesothelioma accompanied by silencing of CDKN2A and loss of p16INK4A and p19ARF proteins, suggesting that epigenetic alterations may play an important role in gene regulation leading to PMe [37].